Institute of Biochemistry and Molecular Medicine
Our research focuses on membrane proteins that transport substances into and out of cells and cell organelles, and the involvement of these proteins in human diseases. The malfunction or dysregulation of membrane transporters and channels has been linked to major human diseases, including diabetes, hypertension, cardiovascular diseases, cancer, osteoporosis, neurodegenerative diseases and psychiatric disorders. Our long-term goal is to integrate membrane transporter research efforts in physiology/medicine, structural biology and chemistry in order to develop novel therapeutic strategies for the treatment of human diseases.
The study of the physiology and pathology of transporters provides the foundation for a detailed mechanistic investigation of clinically relevant transporters. Determination of the structure and function of mammalian transporter proteins is also important in rational ligand-based drug design, the process of finding new drugs based on knowledge of molecules that bind to the transporter or channel of interest. Please click here to read more.