Institute of Biochemistry and Molecular Medicine |
Hediger Group
Prof. Matthias A. Hediger
Institute Director
Contact
For full CV please click here
Research focus:
Our research focuses on membrane proteins that transport substances into and out of cells and cell organelles, and the involvement of these proteins in human diseases. The malfunction or dysregulation of membrane transporters and channels has been linked to major human diseases, including diabetes, hypertension, cardiovascular diseases, cancer, osteoporosis, neurodegenerative diseases and psychiatric disorders. Our long-term goal is to integrate membrane transporter research efforts in physiology/medicine, structural biology and chemistry in order to develop novel therapeutic strategies for the treatment of human diseases.
The study of the physiology and pathology of transporters provides the foundation for a detailed mechanistic investigation of clinically relevant transporters. Determination of the structure and function of mammalian transporter proteins is also important in rational ligand-based drug design, the process of finding new drugs based on knowledge of molecules that bind to the transporter or channel of interest. Please click here to read more.
Current projects:
- Epithelial calcium channels and calcium homeostasis
- Vitamin C and nucleobase transporters (SLC23 family)
- Molecular physiology of iron transport
NCCR TransCure:
International BioMedical Transporter Conferences:
Human transporter genes (SLC series):
Publications
Group members:
- Yvonne Amrein
- Dr. Pascale Anderle Pedone (Bioinformatics Facility)
- Katrin Bissegger
- Dr. Benjamin Clemençon
- Sara El-Gebali
- Maria Feher
- Dr. Michael Fine
- Marie-Christine Franz
- Michèle Frey
- Dr. Gergely Gyimesi
- Dr. Gergely Kovacs
- Dr. Nicolas Montalbetti
- Philipp Schneider
- Dr. Alexandre Simonin (Screening Facility)
- Dr. Daniel Fuster (Junior Group Leader)
- Giuseppe Albano (Fuster Group)
- Manuel Anderegg (Fuster Group)
- Christine Deisl (Fuster Group)
