Institute of Biochemistry and Molecular Medicine

People A-Z
  • 2016 – present: Lecturer and Group Leader at IBMM
  • 2010 – 2015: Swiss National Science Foundation Professor (Assistant Professor) in Bioorganic Chemistry, Department of Chemistry & Biochemistry, University of Bern.
  • 2006 – 2009: Lecturer in Chemical Biology, Department of Chemistry, University of Warwick, UK.
  • 2004 – 2005: Postdoctoral Research Fellow with Prof. Sarah C. R. Lummis, Department of Biochemistry, University of Cambridge, UK. Study of mutant serotonin 5-HT3 receptors as models for heteromeric ligand-gated ion channels.
  • 2003 – 2004: Postdoctoral Research Fellow with Prof. Ian Paterson FRS, Department of Chemistry, University of Cambridge, UK. Working on the total synthesis of the marine, anti-cancer compound Peloruside A.
  • 1998 – 2003: PhD thesis, University of Basel. Synthesis and study of iron porphyrin model compounds as mimics for cytochrome P450 enzymes (group of Prof. Dr. em. Wolf-D. Woggon).
  • 1993 – 1998: Diploma in Chemistry, University of Zürich. Diploma thesis: synthesis of unnatural polyamines (group of late Prof. Dr. Manfred Hesse).

Recent selected publications

  • Wall MJ, Hill E, Huckstepp R, Barkan K, Deganutti G, Leuenberger M, Preti B, Winfield I, Carvalho S, Suchankova A, Wei H, Safitri D, Huang X, Imlach W, La Mache C, Dean E, Hume C, Hayward S, Oliver J, Zhao FY, Spanswick D, Reynolds CA, Lochner M, Ladds G, Frenguelli BG (2022) Selective Activation of Gαob by an Adenosine A1 Receptor Agonist Elicits Analgesia without Cardiorespiratory Depression, Nat Commun 13: 4150 (
  • Leuenberger M, Häusler S, Höhn V, Euler A, Stieger B, Lochner M (2021) Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters, J Pharmacol Ex Ther 377: 346-357 (
  • Schild A, Bhardwaj R, Wenger N, Tscherrig D, Kandasamy P, Dernič J, Baur R, Peinelt C, Hediger MA, Lochner M (2020) Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells, Int J Mol Sci 21: 5604 (
  • Jack T, Leuenberger M, Ruepp MD, Vernekar SKV, Thompson AJ, Braga-Lagache S, Heller M, Lochner M (2019) Mapping the Orthosteric Binding Site of the Human 5-HT3 Receptor Using Photo-crosslinking Antagonists, ACS Chem Neurosci 10: 438-450 (

Click here for all Publications.

  • Swiss Chemical Society
  • Royal Society of Chemistry (MRSC)