Institute of Biochemistry and Molecular Medicine

People A-Z
  • 2016 – present: Lecturer and Group Leader at IBMM
  • 2010 – 2015: Swiss National Science Foundation Professor (Assistant Professor) in Bioorganic Chemistry, Department of Chemistry & Biochemistry, University of Bern.
  • 2006 – 2009: Lecturer in Chemical Biology, Department of Chemistry, University of Warwick, UK.
  • 2004 – 2005: Postdoctoral Research Fellow with Prof. Sarah C. R. Lummis, Department of Biochemistry, University of Cambridge, UK. Study of mutant serotonin 5-HT3 receptors as models for heteromeric ligand-gated ion channels.
  • 2003 – 2004: Postdoctoral Research Fellow with Prof. Ian Paterson FRS, Department of Chemistry, University of Cambridge, UK. Working on the total synthesis of the marine, anti-cancer compound Peloruside A.
  • 1998 – 2003: PhD thesis, University of Basel. Synthesis and study of iron porphyrin model compounds as mimics for cytochrome P450 enzymes (group of Prof. Dr. em. Wolf-D. Woggon).
  • 1993 – 1998: Diploma in Chemistry, University of Zürich. Diploma thesis: synthesis of unnatural polyamines (group of late Prof. Dr. Manfred Hesse).

Recent selected publications

  • [1] Jack T, Leuenberger M, Ruepp MD, Vernekar SKV, Thompson AJ, Braga-Lagache S, Heller M, Lochner M (2019) Mapping the Orthosteric Binding Site of the Human 5-HT3 Receptor Using Photo-crosslinking Antagonists, ACS Chem Neurosci 10: 438-450. doi:10.1021/acschemneuro.8b00327.
  • [2] Mu L, Müller Herde A, Rüefli PM, Sladojevich F, Sephton SM, Krämer SD, Thompson AJ, Schibli R, Ametamey SM, Lochner M (2016) Synthesis and Pharmacological Evaluation of [11C]Granisetron and [18F]Fluoropalonosetron as PET Probes for 5-HT3 Receptor Imaging, ACS Chem Neurosci 7: 1552-1564. doi:10.1021/acschemneuro.6b00192.
  • [3] Leuenberger M, Ritler A, Simonin A, Hediger MA, Lochner M (2016) Concise Asymmetric Synthesis and Pharmacological Characterization of All Stereoisomers of Glutamate Transporter Inhibitor TFB-TBOA and Synthesis of EAAT Photoaffinity Probes, ACS Chem Neurosci 7: 534-539. doi:10.1021/acschemneuro.5b00311.
  • [4] Knight A, Hemmings JL, Winfield I, Leuenberger M, Frattini E, Frenguelli BG, Dowell SJ, Lochner M, Ladds, G (2016) Discovery of Novel Adenosine Receptor Agonists that Exhibit Subtype Selectivity, J Med Chem 59: 947-964. doi:10.1021/acs.jmedchem.5b01402.
  • [5] Jack T, Simonin J, Ruepp MD, Thompson AJ, Gertsch J, Lochner M (2015) Characterizing New Fluorescent Tools for Studying 5-HT3 Receptor Pharmacology, Neuropharmacology 90: 63-73. doi:10.1016/j.neuropharm.2014.11.007.

Click here for all Publications.

  • Swiss Chemical Society
  • Royal Society of Chemistry (MRSC)