Currently we offer the following services:
Screening of compounds on ion channels using the FLIPR Tetra system. The FLIPRTetra is a fluorescence microplate reader used in drug discovery and life sciences research. It is produced by Molecular Devices, a company specializing in bioanalytical measurement systems. The name "FLIPR" stands for Fluorescent Imaging Plate Reader.
Key features and capabilities of the FLIPRTetra include:
- Fluorescence Detection: The FLIPRTetra is designed to detect fluorescence signals emitted by fluorophores. This is particularly useful in applications where changes in fluorescence intensity are indicative of biological processes, such as calcium mobilization in cells.
- Microplate Format: It is configured to read signals from samples in microplates, allowing for high-throughput screening of compounds and experimental conditions. This makes it valuable in drug discovery efforts where rapid and parallel analysis of multiple samples is required.
- Cellular Assays: The FLIPRTetra is commonly used for cellular assays, especially those involving G protein-coupled receptors (GPCRs) and ion channel activity. For example, it is frequently employed in assays that monitor changes in intracellular calcium levels upon stimulation.
- Flexibility: It offers flexibility in terms of assay design, making it suitable for a variety of applications. Researchers can customize experiments to suit their specific needs.
- Automated Liquid Handling: Some configurations of the FLIPRTetra may be integrated with automated liquid handling systems, further streamlining the screening process.
- Software Integration: The instrument is typically accompanied by software for data acquisition and analysis. The software allows researchers to visualize and quantify fluorescence signals, making it easier to interpret experimental results.
Overall, the FLIPRTetra is a versatile and powerful tool for laboratories engaged in drug discovery, functional genomics, and cellular physiology research. It enables the rapid and reliable assessment of cellular responses in a high-throughput manner, making it valuable for screening large compound libraries and studying cellular processes.
90 Fr. per hour plus 20% overhead and VAT
LC-MS/MS based quantification of small molecules (ABISciex 5500, 4000 QTRAPs)
A QTRAP (Quantitative Triple Quadrupole Linear Ion Trap) is a type of mass spectrometer, a sophisticated analytical instrument used in scientific research, particularly in the fields of chemistry, biochemistry, and biology. QTRAP technology combines features of both triple quadrupole and linear ion trap mass spectrometers, offering a versatile platform for various analytical applications.
Here are some key features and capabilities of QTRAP mass spectrometers:
- Triple Quadrupole Functionality:
- QTRAP instruments have the capability of a triple quadrupole mass spectrometer, allowing for highly sensitive and selective detection of target compounds. This is particularly useful in quantitative analysis and targeted experiments.
- Linear Ion Trap Functionality:
- QTRAP instruments also incorporate a linear ion trap, which enables additional capabilities such as enhanced sensitivity in full-scan MS mode, MS/MS experiments, and the ability to perform scans with greater speed and resolution.
- Multiple Reaction Monitoring (MRM):
- QTRAP systems excel in Multiple Reaction Monitoring (MRM), a technique commonly used in quantitative analysis. MRM enhances the selectivity and sensitivity of the mass spectrometer for targeted compound detection.
- Enhanced Sensitivity:
- The QTRAP design often includes features to enhance sensitivity, making it suitable for the detection of low-abundance compounds in complex samples.
- Ion Trap Flexibility:
- The linear ion trap component allows for trapping and storing ions, facilitating MS/MS experiments, and providing flexibility in ion manipulation.
- Hybrid Configuration:
- The hybrid configuration of QTRAP instruments combines the strengths of both triple quadrupole and linear ion trap technologies, offering a comprehensive solution for researchers requiring versatility in their mass spectrometry experiments.
Applications of QTRAP instruments include quantitative analysis of small molecules, targeted proteomics, metabolomics, and drug metabolism studies, among others. The ability to switch between different scan modes and combine triple quadrupole and ion trap functionalities makes QTRAP technology valuable in a wide range of research areas.
We offer preliminary pharmacokinectis (PK), metabolic stability including methods development. Prices in collaboration and on request. A new MRM based method typically costs in the range of 4000-7000 Fr.
We offer specialized cannabinoid and endocannabinoid analytics using LC-MS/MS.
Analysis of C. sativa samples (marihuana, APIs):
110 Fr. per sample (12 cannabinoids) plus 20% overhead and VAT
