The general theme of our research is the chemical synthesis and development of small molecular tools that can be used for the cellular study and chemical modification of ion channels, receptors and transporters. With these molecular probes we aim at complementing molecular biology techniques and offering attractive alternatives to the biological research community. We mainly focus on:
Adenosine is a signalling molecule in the CNS and PNS exerting its action by activating adenosine receptors (A1, A2A, A2B and A3) that belong to the family of G protein-coupled receptors (GPCRs). We have synthesised adenosine derivative BnOCPA, which is a potent and subtype-selective agonist at human A1 receptors. What is more, BnOCPA has a unique and highly selective Gα activation preference and is a potent analgesic without causing bradycardia, hypotension or respiratory depression.
For more details see https://www.biorxiv.org/content/10.1101/2020.04.04.023945v1